Ziverel for PPI-refractory reflux symptoms: efficacy and mechanisms of action in humans

CONCLUSION: Ziverel did not show a benefit on acid sensitivity, reflux symptoms or esophageal mucosal integrity compared to placebo in PPI-refractory patients with reflux symptoms.Trial registration: Netherlands Trial Register number: NL7670.PMID:38088584 | DOI:10.1080/00365521.2023.2290457

Source: Scandinavian Journal of Gastroenterology - December 13, 2023 Category: Gastroenterology Authors: Thijs Kuipers Renske A B Oude Nijhuis Ren é M van den Wijngaard Jac M Oors Andr é J P M Smout Albert J Bredenoord Source Type: research