Syntheses of the ω-pyridinium-containing very-long-chain ceramides PyrCer(24:1(15Z)) and PyrCer(24:0) and their anticancer activity
In this study, we prepared the ω-PyrCers of Cer(24:1(15Z)) and Cer(24:0), PyrCer(24:1(15Z)) and PyrCer(24:0), respectively. The key in the synthesis is the Wittig reaction to prepare the ω-bromo fatty acid with an appropriate chain length and (Z)-double bond position. Preliminary evaluation of the PyrCer(24:1(15Z)) and PyrCer(24:0) revealed their potential in hepatocellular carcinoma treatment.PMID:38086468 | DOI:10.1016/j.bmcl.2023.129585
Source: Bioorganic and Medicinal Chemistry Letters - Category: Chemistry Authors: Ju Young Ko Mi-Yeon Kim Ji-Yoon Jeon Jin Yi Jung Yong-Hyun Han Jae Hyun Kim Source Type: research
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