Viruses, Vol. 15, Pages 2421: Enhancement of SARS-CoV-2 Infection via Crosslinking of Adjacent Spike Proteins by N-Terminal Domain-Targeting Antibodies

In this study, we present refined structural models of NIEA fragment antigen-binding region (Fab)–NTD complexes, supported by molecular dynamics simulations and hydrogen–deuterium exchange mass spectrometry (HDX-MS). Furthermore, we provide direct evidence confirming the crosslinking of spike NTDs by NIEAs. Collectively, our findings advance our understanding of the molecular mechanisms underlying NIEAs and their impact on SARS-CoV-2 infection.

Source: Viruses - December 13, 2023 Category: Virology Authors: Tina Lusiany Tohru Terada Jun-ichi Kishikawa Mika Hirose David Virya Chen Fuminori Sugihara Hendra Saputra Ismanto Floris J. van Eerden Songling Li Takayuki Kato Hisashi Arase Matsuura Yoshiharu Masato Okada Daron M. Standley Tags: Article Source Type: research