Deep intronic 9q21.11 polymorphism contributes to atopic dermatitis risk through methylation regulated expression of tight junction protein 2

CONCLUSION: Epigenetic influence at CpG site cg13920460 is associated with rs7872806 located deep intronic at 9q21.11. The SNP confers susceptibility to AD through altering TJP2 expression and promoting trans-epidermal water loss.PMID:38085524 | DOI:10.18176/jiaci.0978

Source: Journal of Investigational Allergology and Clinical Immunology - December 12, 2023 Category: Allergy & Immunology Authors: Y Y Eliza Lim Y Yie Sio Y H Say K Reginald F Tim Chew Source Type: research