PET/CT shows impact of different COVID-19 vaccines

The type of COVID-19 vaccine and the time interval between vaccination and PET/CT scans are key factors in minimizing false interpretations in cancer patients, according to research published December 9 in Scientific Reports. The study is the first to examine systemic response changes in patients in correlation to time after COVID-19 vaccination using three different vaccines, and may help minimize dilemmas for clinicians, wrote first author Tina Nazerani-Zemann, MD, of the Medical University of Graz in Austria, and colleagues. “Different vaccines cause different system metabolic changes. The knowledge of vaccine type, the time interval between vaccination and PET/CT scan is essential, especially in therapy evaluation,” the group noted. Previous studies have shown that COVID-19 vaccines can cause axillary lymphadenopathy and that this may mimic activity typically associated with metastasis in oncologic patients, the authors explained. “As the vaccination program continues, we encountered increased F-18 FDG-activity not only in axillary lymph nodes ipsilateral to the injection site but also in other organs,” the authors noted. To further elucidate cancer patient reactions to COVID-19 vaccines, the authors aimed to show any systemic metabolic changes after vaccination with three different vaccines in relation to time. The group collected data on 220 eligible vaccinated cancer patients (127 with the Pfizer-BioNTech vaccine, 61 with the Moderna, and 32 with AstraZen...
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