Acute ischemia induces spatially and transcriptionally distinct microglial subclusters

ConclusionsICAM could induce excessive neuroinflammation, aggravating brain injury, whereas IPAM probably exhibit neuroprotective features, which could be essential for the homeostasis and survival of cells in the penumbra. Our findings provide a biological basis for targeting specific microglial subclusters as a potential therapeutic strategy for ischemic stroke.
Source: Genome Medicine - Category: Genetics & Stem Cells Source Type: research