Hypoxia ‐induced cystic fibrosis transmembrane conductance regulator dysfunction is a universal mechanism underlying reduced mucociliary transport in sinusitis

ConclusionHypoxia induces severe CFTR dysfunction via free radical production causing reduced MCT in vitro and in vivo. Improved oxygenation is critical to reducing the impact of persistent mucociliary dysfunction.

Source: International Forum of Allergy and Rhinology - December 11, 2023 Category: Allergy & Immunology Authors: Do ‐Yeon Cho, Shaoyan Zhang, T. Graham Norwood, Daniel Skinner, Tonja A. Hollis, Marie L. Ehrhardt, Lydia C. Yang, Dong‐Jin Lim, Jessica W. Grayson, Ahmed Lazrak, Sadis Matalon, Steven M. Rowe, Bradford A. Woodworth Tags: ORIGINAL ARTICLE Source Type: research