Hepatic prohibitin 1 and methionine adenosyltransferase α1 defend against primary and secondary liver cancer metastasis

Liver is a common site of cancer metastasis (a.k.a. secondary liver cancer, most commonly from colorectal cancer (CRC)) and primary liver cancers that have metastasized have poor prognosis. The underlying mechanisms of how the liver defends against these processes are largely unknown. Prohibitin 1 (PHB1) and methionine adenosyltransferase 1A (MAT1A) are highly expressed in the liver. They positively regulate each other and their deletion results in primary liver cancer. Here we investigated their roles in primary and secondary liver cancer metastasis.

Source: Journal of Hepatology - December 10, 2023 Category: Gastroenterology Authors: Wei Fan, DuoYao Cao, Bing Yang, Jiaohong Wang, Xiaomo Li, Diana Kitka, Tony W.H. Li, Sungyong You, Stephen Shiao, Alexandra Gangi, Edwin Posadas, Dolores Di Vizio, Maria Lauda Tomasi, Ekihiro Seki, Jos é M. Mato, Heping Yang, Shelly C. Lu Tags: Research Article Source Type: research