Age- and sex-related oculomotor manifestation of dopamine deficiency in Segawa disease

CONCLUSIONS: The findings can be explained by a dysfunction of the BG-direct pathway impinging on superior colliculus (SC) due to dopamine deficiency. The disturbed inhibitory control of saccades may be explained by increased SC responsivity to visual stimuli.SIGNIFICANCE: Oculomotor abnormalities in SD can be explained by dysfunction of the BG inhibitory pathways reaching SC, with a delayed maturation in male SD patients, consistent with previous pathological/physiological studies.PMID:38064930 | DOI:10.1016/j.clinph.2023.11.010

Source: Clinical Neurophysiology - December 8, 2023 Category: Neurology Authors: Yasuo Terao Hideki Fukuda Okihide Hikosaka Akihiro Yugeta Shun-Ichi Matsuda Francesco Fisicaro Yoshikazu Ugawa Kyoko Hoshino Yoshiko Nomura Source Type: research