GLP-1 receptor signaling has different effects on the perikarya and axons of the hypophysiotropic thyrotropin-releasing hormone synthesizing neurons in male mice

CONCLUSIONS: Our results indicate that GLP-1R activation has direct stimulatory effect on TRH neurons in the PVN, but the activation of GLP-1R may also inhibit TRH neurons by facilitating their inhibitory inputs or by inhibiting the axon terminals of these cells in the median eminence. The innervation of TRH neurons by GLP-1 neurons suggests that TRH neurons might be influenced by both circulating GLP-1 and by GLP-1 neurons of the nucleus tractus solitarii. The lack of GLP-1R agonist induced regulation of TRH neurons in vivo suggests that the HPT axis does not mediate the GLP-1 receptor agonist-induced weight loss.PMID:38062754 | DOI:10.1089/thy.2023.0284
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Authors: Source Type: research