Ex vivo Hematopoietic Stem Cell Expansion Technologies: Recent Progress, Applications, and Open Questions

Hematopoietic stem cells (HSCs) are a rare but powerful cell type with the role of supporting blood and immune cell production throughout our lives. It is estimated that there are only ∼100,000 active HSCs in adult humans yet they are responsible for generating ∼90% of the cells in our bodies1,2. HSCs can also stably regenerate the entire blood and immune system following transplantation. To achieve these functions, HSCs balance self-renewal to generate more stem cells and dif ferentiation to generate any of the mature blood cell types via a spectrum of intermediate progenitor cells3.
Source: Experimental Hematology - Category: Hematology Authors: Source Type: research