EML4-ALK Variant 3a/b as a mechanism of osimertinib resistance in a patient with EGFR L858R positive NSCLC

In September 2019, a 74-year-old woman was introduced to our hospital because of persistent right chest pain. She had a history of smoking (50 pack-years) and had undergone surgery for right breast cancer at 40 years of age without recurrence. Chest computed tomography (CT) revealed a mass in the upper lobe of the right lung (Figure 1A). She underwent CT-guided lung biopsy and was diagnosed with lung adenocarcinoma stage IVB (cT4N2M1c) with multiple lung and bone metastases. Bone metastases were detected in the transverse processes of the thoracic spine on PET at diagnosis; however, the effect of treatment was difficult to assess on CT due to the nature of the lesion.

Source: Cancer Genetics and Cytogenetics - December 8, 2023 Category: Genetics & Stem Cells Authors: Teppei Yamaguchi, Katsuhiro Masago, Eiichi Sasaki, Hiroaki Kuroda, Hirokazu Matsushita, Yoshitsugu Horio Tags: Case Report Source Type: research