Lack of S1PR2 in Macrophage Ameliorates Sepsis-associated Lung Injury through Inducing IL-33-mediated Type 2 Immunity

In conclusion, a lack of S1PR2 modulates type 2 immune response by upregulating IL-33 release from macrophages and alleviates sepsis-induced lung injury. Targeting S1PR2 may have a potential therapeutic value for sepsis treatment.PMID:38061028 | DOI:10.1165/rcmb.2023-0075OC

Source: Am J Respir Cell Mol... - December 7, 2023 Category: Respiratory Medicine Authors: Chenchen Gong Yue Jin Xi Wang Jiali Mao Dongdong Wang Xiangyang Yu Shiyu Chen Yang Wang Daqing Ma Xiangming Fang Kai Zhang Qiang Shu Source Type: research