Nuclear RNA catabolism controls endogenous retroviruses, gene expression asymmetry, and dedifferentiation

Torre et  al. report a functional role of the RNA exosome and Integrator in regulating cell identity, ERV expression, and RNAPII elongation in embryonic stem cells. Disrupting either of these complexes promotes a totipotent-like 2CLC state, downregulating pluripotency genes, reducing transcriptional elongat ion, and primarily affecting long, multi-exonic genes.

Source: Molecular Cell - November 22, 2023 Category: Cytology Authors: Denis Torre, Yesai S. Fstkchyan, Jessica Sook Yuin Ho, Youngseo Cheon, Roosheel S. Patel, Emma J. Degrace, Slim Mzoughi, Megan Schwarz, Kevin Mohammed, Ji-Seon Seo, Raquel Romero-Bueno, Deniz Demircioglu, Dan Hasson, Weijing Tang, Sameehan U. Mahajani, La Tags: Article Source Type: research