Micrornas expression profile in skeletal muscle of patients with gastrointestinal cancer

Rationale: microRNAs (miRs) were shown to regulate signaling pathways involved in the pathogenesis of cancer cachexia (CC). However, their biological roles in CC are still poorly explored. Aim of this study was to evaluate the expression of muscle-derived miR486-5p and miR15b-5p, which both have been found to have a regulatory effect on inflammatory pathways as well as on modulation of protein synthesis and skeletal muscle (SM) homeostasis, making them attractive as early non-invasive diagnostic targets and potential novel therapeutic candidates for CC.
Source: Clinical Nutrition ESPEN - Category: Nutrition Authors: Source Type: research