Xylarcurcosides A-C, three novel isopimarane-type diterpene glycosides from Xylaria curta YSJ-5

Carbohydr Res. 2023 Nov 23;535:108987. doi: 10.1016/j.carres.2023.108987. Online ahead of print.ABSTRACTThree previously undescribed isopimarane-type diterpene glycosides named as xylarcurcosides A-C (1-3) along with two known ones 16-α-d-mannopyranosyloxyisopimar-7-en-19-oic acid (4) and hypoxylonoid A (5) were successfully isolated from an ethyl acetate extract of the endophytic fungus Xylaria curta YSJ-5 growing in leaves of Alpinia zerumbet. The spectroscopic methods, electronic circular dichroism (ECD) calculations, and X-ray diffraction experiments were conducted to identify their absolute chemical structures. All these compounds were tested for in vitro cytotoxic, anti-inflammatory, α-glucosidase inhibitory, and antibacterial activities. As a result, these novel compounds demonstrated no obvious cytotoxic and antibacterial activity.PMID:38048745 | DOI:10.1016/j.carres.2023.108987

Source: Carbohydrate Research - December 4, 2023 Category: Genetics & Stem Cells Authors: Shanshan Wei Chen Chen Jiaying Lai Yanjiang Zhang Xinmiao Nong Fangfang Duan Ping Wu Sasa Wang Haibo Tan Source Type: research