Pyruvate dehydrogenase is a potential mitochondrial off-target for gentamicin based on in silico predictions and in vitro inhibition studies

In conclusion, the use of in silico methods appeared a valuable approach in predicting PDH as a mitochondrial off-target of gentamicin. Further research is required to investigate the contribution of PDH inhibition to overall renal toxicity of gentamicin.PMID:38036072 | DOI:10.1016/j.tiv.2023.105740

Source: Toxicology in Vitro - November 30, 2023 Category: Toxicology Authors: Charlotte A Hoogstraten Jan B Koenderink Carolijn E van Straaten Tom Scheer-Weijers Jan A M Smeitink Tom J J Schirris Frans G M Russel Source Type: research