Cyclooxygenase-2 inhibition prevents renal toxicity but not hypertension during sunitinib treatment

CONCLUSION: Selective COX-2 inhibition ameliorates albuminuria during angiogenesis inhibition, which most likely acts independently of PGI2. To combat angiogenesis inhibitor-induced hypertension, dual rather than selective COX-1/2 blockade seems preferential.PMID:38029870 | DOI:10.1016/j.ejphar.2023.176199

Source: European Journal of Pharmacology - November 29, 2023 Category: Drugs & Pharmacology Authors: Daan C H van Dorst Katrina M Mirabito Colafella Richard van Veghel Ingrid M Garrelds Ren é de Vries Ron H J Mathijssen A H Jan Danser Jorie Versmissen Source Type: research