Favorable outcome without corticosteroids during post-artesunate delayed hemolysis with positive direct antiglobulin test in severe imported Plasmodium falciparum malaria, France

Post-artesunate delayed hemolysis (PADH) is a common nonrecurring adverse effect of artesunate during severe Plasmodium falciparum malaria, which occurs after the first week of treatment in an estimated 10-30% of cases in nonimmune travelers [1,2]. Reports of positive direct antiglobulin tests (DAT) in patients experiencing PADH suggest an immune-driven process [1,3]. In a systematic review, 44% of patients with PADH had a positive DAT [4]. Most previous reports focused only on patients experiencing PADH and not on other patients with severe malaria.

Source: International Journal of Infectious Diseases - November 3, 2023 Category: Infectious Diseases Authors: Olivier Paccoud, Xavier Chamillard, Eric Kendjo, Isabelle Vinatier, Laure Surgers, Denis Magne, Benjamin Wyplosz, Ad éla Angoulvant, Olivier Bouchaud, Arezki Izri, Sophie Matheron, Sandrine Houzé, Marc Thellier, Alioune P. Ndour, Pierre Buffet, Eric Cau Tags: Short Communication Source Type: research