Aortic aneurysms: current pathogenesis and therapeutic targets

Experimental & Molecular Medicine, Published online: 01 December 2023; doi:10.1038/s12276-023-01130-wAortic aneurysms, a chronic aortic disease, can lead to life-threatening consequences. Recent advancements in understanding the pathophysiological mechanisms of aortic aneurysms have focused on the source of therapeutic targets. The heterogeneity of aortic cells during the progress of an aortic aneurysm is augmented by the alteration of gene expression that changes the phenotype and function of the aortic cells. Inflammatory cells, cytokines production, matrix metalloproteinases, smooth muscle cells phenotypic switching, SMCs death, neovascularization, and thrombosis contribute to the development and progression of aortic aneurysms. Neutralization of transforming growth factor-β in mouse aortic aneurysm models exhibits different consequences in the progress of aortic aneurysms depending on experimental designs. Extracellular vesicles contain various contents with biological activity and are released from donor cells to target cells or organs, potentially promoting or preventing the progress of aortic aneurysms.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.
Source: Experimental and Molecular Medicine - Category: Molecular Biology Authors: Source Type: research