Disruption of cholesterol homeostasis triggers periodontal inflammation and alveolar bone loss

Experimental & Molecular Medicine, Published online: 01 December 2023; doi:10.1038/s12276-023-01122-wHypercholesterolemia, a type of hyperlipidemia, has been identified as a key factor in the development of periodontitis. This groundbreaking study by Tran et al. uncovers the complex mechanisms behind this association, revealing how an excess of cholesterol can trigger periodontal inflammation and alveolar bone loss. The researchers found that cholesterol dysregulation in periodontal cells, caused by increased CXCL16-mediated cholesterol influx and production of oxysterol metabolites by CH25H, stimulates the release of inflammatory mediators. This can lead to systemic diseases when released into the bloodstream. The study also highlighted the role of nuclear receptor RORĪ± in mediating periodontitis pathogenesis triggered by cholesterol and its metabolites. These findings pave the way for new therapeutic approaches targeting individual molecular pathogenesis pathways in periodontitis treatment. This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.
Source: Experimental and Molecular Medicine - Category: Molecular Biology Authors: Source Type: research