Interaction of fentanyl with various cyclodextrins in aqueous solutions

ConclusionsThis study revealed that hydrophilic β‐CD derivatives, such as G1‐β‐CD, could be useful pharmaceutical additives for oral mucosal formulations because of the improved fentanyl base solubility via inclusion complexation.

Source: Journal of Pharmacy and Pharmacology - June 16, 2015 Category: Drugs & Pharmacology Authors: Noriko Ogawa, Takayuki Furuishi, Hiromasa Nagase, Tomohiro Endo, Chisato Takahashi, Hiromitsu Yamamoto, Yoshiaki Kawashima, Thorsteinn Loftsson, Masaru Kobayashi, Haruhisa Ueda Tags: Research Paper Source Type: research