Fatty acid binding protein 5 inhibition attenuates pronociceptive cytokine/chemokine expression and suppresses osteoarthritis pain: A comparative human and rat study

Osteoarthritis (OA) is often accompanied by debilitating pain that is refractory to available analgesics due in part to the complexity of signaling molecules that drive OA pain and our inability to target these in parallel. Fatty acid binding protein 5 (FABP5) is a lipid chaperone that regulates inflammatory pain; however, its contribution to OA pain has not been characterized.

Source: Osteoarthritis and Cartilage - November 27, 2023 Category: Rheumatology Authors: Chris Gordon, James Trainor, Rohan J. Shah, Keith Studholme, Alex Gelman, Faniya Doswell, Faisal Sadar, Allessio Giovannetti, Josh Gershenson, Ayesha Khan, James Nicholson, ZeYu Huang, Michael Spurgat, Shao-Jun Tang, Hehe Wang, Iwao Ojima, David Carlson, Source Type: research