Sox9 is associated with two distinct patterning events during snake lung morphogenesis

Dev Biol. 2023 Nov 21:S0012-1606(23)00189-6. doi: 10.1016/j.ydbio.2023.11.006. Online ahead of print.ABSTRACTThe evolutionary forces that allowed species adaptation to different terrestrial environments and led to great diversity in body shape and size required acquisition of innovative strategies of pattern formation during organogenesis. An extreme example is the formation of highly elongated viscera in snakes. What developmental patterning strategies allowed it to overcome the space constraints of the snake's body to meet physiological demands? Here we show that the corn snake uses a Sox2-Sox9 developmental tool kit common to other species to generate and shape the lung in two phases. Initially Sox9 was found at low levels at the tip of the primary lung bud during outgrowth and elongation of the bronchial bud, without driving branching programs characteristic of mammalian lungs. Later, Sox9 induction is recapitulated in the formation of an extensive network of radial septae emerging along the elongated bronchial bud that generates the respiratory region. We propose that altogether these represent key patterning events for formation of both the respiratory faveolar and non-respiratory posterior compartments of the snake lungs.PMID:37995917 | DOI:10.1016/j.ydbio.2023.11.006

Source: Developmental Biology - November 23, 2023 Category: Biology Authors: Benjamin J van Soldt Brian D Metscher Michael K Richardson Wellington V Cardoso Source Type: research