Review and prospects of targeted therapies for Spleen tyrosine kinase (SYK)

This article reviews the biological function of SYK, the relationship between SYK and disease, and therapies targeting SYK. In addition, inspired by new technologies such as proteolysis targeting chimeras (PROTACs) and phosphatase recruiting chimeras (PHORCs), we propose the development of new therapeutic approaches for targeting SYK, such as SYK PROTACs and SYK PHORCs, which may overcome deficiencies of existing methods.PMID:37984216 | DOI:10.1016/j.bmc.2023.117514

Source: Bioorganic and Medicinal Chemistry - November 20, 2023 Category: Chemistry Authors: Zhaozhao Wang Shu Qu Jiahao Yuan Wen Tian Jinglei Xu Rui Tao Shilong Sun Tao Lu Weifang Tang Yong Zhu Source Type: research