Emerging Role of Astrocyte-Derived Extracellular Vesicles as Active Participants in CNS Neuroimmune Responses

Immunol Invest. 2023 Nov 19:1-14. doi: 10.1080/08820139.2023.2281621. Online ahead of print.ABSTRACTAstrocyte-derived extracellular vesicles (ADEVs) have garnered attention as a fundamental mechanism of intercellular communication in health and disease. In the context of neurological diseases, for which prodromal diagnosis would be advantageous, ADEVs are also being explored for their potential utility as biomarkers. In this review, we provide the current state of data supporting our understanding on the manifold roles of ADEVs in several common neurological disorders. We also discuss these findings from a unique emerging perspective that ADEVs represent a means by which the central nervous system may broadcast influence over other systems in the body to affect neuroinflammatory processes, with both dual potential to either propagate illness or restore health and homeostasis.PMID:37981468 | DOI:10.1080/08820139.2023.2281621
Source: Immunological Investigations - Category: Allergy & Immunology Authors: Source Type: research