CREB-induced LINC00473 promotes chemoresistance to TMZ in glioblastoma by regulating O6-methylguanine-DNA-methyltransferase expression via CEBP α binding

In conclusion, a novel CREB/LINC00473/CEBPα/MGMT pathway was revealed in the GB TMZ-resistance formation. In addition, an exosome-based mechanism of chemoresistance transmission was revealed, which suggested that LINC00473 could be used as a novel therapeutic target for GB.PMID:37981063 | DOI:10.1016/j.neuropharm.2023.109790

Source: Neuropharmacology - November 19, 2023 Category: Drugs & Pharmacology Authors: Li-Ya Jiang Guan-Hao Wang Jing-Jiao Xu Xiao-Li Li Xiao-Yan Lin Xiang Fang Hong-Xu Zhang Mei Feng Chun-Ming Jiang Source Type: research