Administration of a glypican ‐3 peptide increases the infiltration and cytotoxicity of CD8+ T cells against testicular yolk sac tumor, associated with enhancing the intratumoral cGAS/STING signaling

ConclusionsThese data indicated that GPC3 peptide-specific CD8+ T cells had potent antitumor activity against TYST tumor, particularly for combined treatment with the peptide, which was partially dependent on the intratumoral cGAS/STNG signaling. GPC3 peptide vaccine may be valuable for the combination treatment of TYST.

Source: Cancer Medicine - November 21, 2023 Category: Cancer & Oncology Authors: Junfeng Zhao, Le Qin, Guorong He, Tiancheng Xie, Guanghui Hu, Furan Wang, Hongji Zhong, Jianming Zhu, Yunfei Xu Tags: RESEARCH ARTICLE Source Type: research