Mild traumatic brain injury-induced persistent blood –brain barrier disruption is prevented by cyclosporine A treatment in hypertension

DiscussionWe propose that mTBI and hypertension interact to promote BBB disruption via the CyPA-NF-kB-MMP-9 pathway, and inhibition of cyclophilin production after mTBI may exert neuroprotection and improve cognitive function in hypertensive patients.
Source: Frontiers in Neurology - Category: Neurology Source Type: research