Composite paraganglioma-ganglioneuroma with atypical catecholamine profile and phenylethanolamine N-methyltransferase expression: a case report and literature review

We present the case of a 46-year-old woman with an atypical catecholamine profile who was preoperatively diagnosed with pheochromocytoma. However, postoperative pathology revealed that the patient had an extra-adrenal paraganglioma accompanied by a ganglioneuroma, which led to the diagnosis of a composite tumor. Interestingly, PNMT is expressed in both paragangliomas and ganglioneuromas. In addition, we reviewed reported composite paragangliomas and compared their clinical features with those of composite pheochromocytomas. We also discuss various aspects of the etiology of composite paragangliomas and the mechanism by which PNMT is expressed in tumors.PMID:37952980 | DOI:10.1507/endocrj.EJ23-0271

Source: Endocrine Journal - November 12, 2023 Category: Endocrinology Authors: Yuriko Sasaki Maki Kanzawa Masaaki Yamamoto Keitaro Kanie Hironori Bando Kei Yoshino Yushi Hirota Katsumi Shigemura Masato Fujisawa Wataru Ogawa Hidenori Fukuoka Source Type: research