Pathogenic role of anti-cN1A autoantibodies in sporadic inclusion body myositis

Conclusions
Active cN1A peptide immunisation partially reproduced the clinical and histological aspects of sIBM in wild-type mice. The murine model demonstrates the pathogenic properties of anti-cN1A autoantibodies to cause sIBM-like histological changes.

Source: Journal of Neurology, Neurosurgery and Psychiatry - November 15, 2023 Category: Neurosurgery Authors: Yamashita, S., Tawara, N., Zhang, Z., Nakane, S., Sugie, K., Suzuki, N., Nishino, I., Aoki, M. Tags: Neuromuscular Source Type: research