TLR4 antagonism provides short-term but not long-term clinical benefit in a full-depth cartilage defect mouse model

CONCLUSIONS: Collectively, this work demonstrates that systemic treatment with a TLR4 antagonist is protective to further cartilage damage 14-days post-injury in a murine model of induced disease.PMID:37898909 | DOI:10.1080/03008207.2023.2269257

Source: Connective Tissue Research - October 29, 2023 Category: Research Authors: Ariel E Timkovich G Aaron Holling Maryam F Afzali John Kisiday Kelly S Santangelo Source Type: research