A multimodality assessment of the protective capacity of statin therapy in a mouse model of radiation cardiotoxicity

Radiation cardiotoxicity (RC) is a common adverse effect following treatment for intrathoracic malignancy [1 –4]. Depending on the dose distribution, cardiac substructure irradiation can lead to a range of symptomatic conditions including ischaemia, arrhythmia, valvopathy and pericardial disease in the months-to-years after treatment, and typically with a chronic component [5,6]. Symptomatic or occult ca rdiac tissue damage [7,8] may increase the risk of death by impairing cardiac function during unrelated acute physiological challenges.
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research