Cardiac radiation dose is associated with inferior survival but not cardiac events in patients with locally advanced non-small cell lung cancer in the era of immune checkpoint inhibitor consolidation

Patients with lung cancer often have pre-existing cardiovascular comorbidity and receive potentially cardiotoxic therapies, including radiation therapy (RT). In RTOG 0617, higher cardiac radiation dose was associated with worse overall survival (OS) in patients with unresectable, locally advanced non-small cell lung cancer (LA-NSCLC) treated with concurrent chemoradiation therapy (cCRT) [1]. One hypothesis is that higher cardiac dose was associated with cardiac events, and these cardiac events led to worse OS.

Source: Radiotherapy and Oncology - November 14, 2023 Category: Radiology Authors: Nikhil Yegya-Raman, Sang Ho Lee, Cole Friedes, Xingmei Wang, Michelle Iocolano, Timothy P. Kegelman, Lian Duan, Bolin Li, Eva Berlin, Kristine N. Kim, Abigail Doucette, Srinivas Denduluri, William P. Levin, Keith A. Cengel, Roger B. Cohen, Corey J. Langer Tags: Original Article Source Type: research