Single cell-resolved study of advanced murine MASH reveals a homeostatic pericyte signaling module

Metabolic dysfunction-associated steatohepatitis (MASH) is linked to insulin resistance and type II-diabetes and marked by hepatic inflammation, microvascular dysfunction, and fibrosis, impairing liver function and aggravating metabolic derangements. Liver homeostatic interactions disrupted in MASH are still poorly understood. We aimed to elucidate the plasticity and changing interactions of non-parenchymal cells associated with advanced MASH.

Source: Journal of Hepatology - November 14, 2023 Category: Gastroenterology Authors: Sofie M. Bendixen, Peter R. Jakobsgaard, Daniel Hansen, Kamilla H. Hejn, Mike K. Terkelsen, Frederik A. Bjerre, Annemette P. Thulesen, Niels G. Eriksen, Philip Hallenborg, Yana Geng, Trine V. Dam, Frederik T. Larsen, Charlotte W. Wernberg, Janusa Vijayath Tags: Research Article Source Type: research