'Enhancing' skeletal muscle and stem cells in three-dimensional: genome regulation of skeletal muscle in development and disease

Curr Opin Genet Dev. 2023 Nov 9;83:102133. doi: 10.1016/j.gde.2023.102133. Online ahead of print.ABSTRACTThe noncoding genome imparts important regulatory control over gene expression. In particular, gene enhancers represent a critical layer of control that integrates developmental and differentiation signals outside the cell into transcriptional outputs inside the cell. Recently, there has been an explosion in genomic techniques to probe enhancer control, function, and regulation. How enhancers are regulated and integrate signals in stem cell development and differentiation is largely an open question. In this review, we focus on the role gene enhancers play in muscle stem cell specification, differentiation, and progression. We pay specific attention toward the identification of muscle-specific enhancers, the binding of transcription factors to these enhancers, and how enhancers communicate to their target genes via three-dimensional looping.PMID:37951138 | DOI:10.1016/j.gde.2023.102133
Source: Current Opinion in Genetics and Development - Category: Genetics & Stem Cells Authors: Source Type: research