Induction of ferroptosis by photodynamic therapy and enhancement of antitumor effect with ferroptosis inducers

ConclusionThis study found that the mechanism underlying TS-PDT-induced ferroptosis constitutes direct lipid peroxidation by the generated ROS, and the inhibition of system xc−, and that the combination of a ferroptosis inducer with TS-PDT enhances the antitumor effect of TS-PDT. Our findings suggest that ferroptosis-inducing therapies combined with PDT may benefit cancer patients.

http://link.springer.com/10.1007/s00535-023-02054-y

Source: Journal of Gastroenterology - November 10, 2023 Category: Gastroenterology Source Type: research