Youth-associated platelet-derived chemokine reverses brain aging through neuroimmune mechanisms
Trends Mol Med. 2023 Nov 7:S1471-4914(23)00250-2. doi: 10.1016/j.molmed.2023.10.007. Online ahead of print.ABSTRACTAge-related loss of brain function has been seen as inevitable, yet recent work leveraging the systemic environment challenges this notion. Schroer et al. demonstrate that youth-associated platelet factor 4 (PF4) partially restores brain function in aged mice while reducing peripheral immune dysfunction, supporting periphery-based approaches to treat age-associated brain disorders.PMID:37945435 | DOI:10.1016/j.molmed.2023.10.007
Source: Trends in Molecular Medicine - Category: Molecular Biology Authors: Brittany M Hemmer Sarah M Philippi Joseph M Castellano Source Type: research