A provider survey assessing fetal impact of CFTR modulator use in males with CF during assisted and unassisted reproduction and partner pregnancy

In 1968, Kaplan and colleagues concluded from their case series that the majority of males with cystic fibrosis (mwCF) are infertile as a result of congenital bilateral absence of the vas deferens. They noted that while the testes in mwCF were often normal in volume, histological examination revealed decreased spermatogenesis and abnormal sperm mophology.1 Subsequent work has demonstrated that approximately 98  % of males with CF are infertile, dependent on their CFTR variants.2 Nonetheless, through use of assisted reproductive technologies (ART), including surgical sperm retrieval, intracytoplasmic sperm injection, and embryo implantation, mwCF can achieve partner pregnancy.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Short Communication Source Type: research