Bone morphogenetic protein 6 induces downregulation of pentraxin 3 expression in human granulosa lutein cells in women with polycystic ovary syndrome

ConclusionsThe suppressive effect of BMP6 on PTX3 was mediated by ALK2/ALK3 type  I receptors and BMPR2/ACVR2A type II receptors in granulosa cells through the SMAD1/5-SMAD4 dependent signaling pathway in PCOS.Our findings provides new insights into the understanding of the pathogenesis of PCOS-related ovulatory disorders.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research