Rapid dynamic changes of FL.2 variant: a case report of COVID-19 breakthrough infection.

Immune responses within the context of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vary. Typically the virus is cleared within 2 weeks of infection but immunocompromised individuals can have prolonged infections[1, 2]. Weak immune systems increase infection risk and post-COVID-19 clinical sequelae, even post-vaccination[3]. Prolonged infections may facilitate viral evolution, including the evolution of immune-evasive viral variants. SARS-CoV-2 variants of concern (VOCs) such as Alpha, Beta and Gamma may have originated within the context of long-term infections in immunocompromised individuals[4-6].

Source: International Journal of Infectious Diseases - November 10, 2023 Category: Infectious Diseases Authors: Wonderful T. Choga, Gobuiwang Khilly Kurusa (Gasenna), James Emmanuel San, Tidimalo Ookame, Irene Gobe, Mohammed Chand, Badisa Phafane, Kedumetse Seru, Patience Matshosi, Boitumelo Zuze, Nokuthula Ndlovu, Teko Matsuru, Dorcas Maruapula, Ontlametse T. Bare Tags: Case Report Source Type: research