Synthesis and Antimicrobial Activity of Phthalide Derivatives of Cytisine, Anabasine, and Salsoline

Aminophthalide derivatives of cytisine, anabasine, and salsoline were obtained in high yields via condensation of the alkaloids with o-formylbenzoic acid. Their structures were proven using1H and13C NMR spectroscopy and data from 2D COSY1H –1H and HMQC1H –13C spectra. Studies of their antimicrobial activity showed moderate antimicrobial activity of 3-(N-cytisin-1-yl)isobenzofuran-1(3H)-one and 3-(N-salsolin-1-yl)isobenzofuran-1(3H)-one against Gram-positive test strainStaphylococcus aureus ATCC 6538 and Gram-negative test strainEscherichia coli ATCC 25922.
Source: Chemistry of Natural Compounds - Category: Chemistry Source Type: research