Disease activity drives transcriptomic heterogeneity in early untreated rheumatoid synovitis

Conclusion
In this large series of early, untreated RA, we show that the synovial transcriptome closely mirrors clinical disease activity and correlates with synovial inflammation. Intriguingly, lower inflammation and disease activity are associated with higher ratios of M2:M1 macrophages, particularly striking in the synovial lining layer. This may point to a protective role for tissue resident macrophages in RA.

Source: Annals of the Rheumatic Diseases - November 10, 2023 Category: Rheumatology Authors: Triaille, C., Tilman, G., Sokolova, T., Loriot, A., Marchandise, J., De Montjoye, S., Nzeusseu-Toukap, A., Meric de Bellefon, L., Bouzin, C., Galant, C., Durez, P., Lauwerys, B. R., Limaye, N. Tags: Open access, ARD, Early arthritis Source Type: research