Altered p53/p16 expression is linked to urothelial carcinoma progression but largely unrelated to prognosis in muscle-invasive tumors

CONCLUSION: Aberrant p53 and p16 immunostaining increases during grade and stage progression although p53 negative and p16 positive immunostaining lack prognostic significance in pT2-4 carcinomas. Potential diagnostic features are that high level p16 expression is limited to neoplastic urothelium and p53 null phenotype to aggressive cancers (grade 3 and invasive).PMID:37938166 | DOI:10.1080/0284186X.2023.2277344

Source: Acta Oncologica - November 8, 2023 Category: Cancer & Oncology Authors: Simon Schallenberg Henning Plage Sebastian Hofbauer Kira Furlano Sarah Weinberger Paul Giacomo Bruch Florian Ro ßner Sefer Elezkurtaj Martina Kluth Maximilian Lennartz Niclas C Blessin Andreas H Marx Henrik Samtleben Margit Fisch Michael Rink Marcin Sloj Source Type: research