3-acetylpyridine induced behavioral dysfunction and neuronal loss in the striatum and hippocampus of adult male rats

Ann Anat. 2023 Nov 7:152185. doi: 10.1016/j.aanat.2023.152185. Online ahead of print.ABSTRACT3-acetylpyridine (3-AP) is a neurotoxin that is known to mainly affect the inferior olivary nucleus (ION) in the brain stem. Although several studies have explored the effect of this neurotoxin, still further investigation is required to understand the impact of this toxin on different parts of the brain. In this research, two groups of rats were studied, the 3-AP-treated and the control groups. Behavioral, stereological, and immunohistochemical analyses were performed. The locomotor activity of the 3-AP-treated rats decreased whereas their anxiety levels were higher than in normal controls. Also, memory performance was impaired in animals in the 3-AP group. Microscopic observations showed a decline in the numerical density of neurons in the hippocampus and striatum along with gliosis. Although this toxin is used to affect the ION, it exerts a neurotoxic effect on different brain regions.PMID:37944830 | DOI:10.1016/j.aanat.2023.152185

Source: Annals of Anatomy - November 9, 2023 Category: Anatomy Authors: Zeynab Ghorbani Mojtaba Sani Zahra Aghighi Meysam Hassani Moghaddam Neda Eskandari Esmaeil Mohammadbagheri Mobina Fathi Zahra Shenasandeh Farid Fotouhi Mohammad-Amin Abdollahifar Mina Salehi Amir-Hossein Bayat Gholam Hossein Meftahi Abbas Aliaghaei Homa R Source Type: research