Identification of prognostic biomarkers for antibiotic associated nephrotoxicity in cystic fibrosis

Life expectancy in cystic fibrosis (CF) is near 50 years, thanks to novel therapies and improved diagnostics [1]. This remarkable progress is attenuated by an increasing prevalence of comorbidities. In CF, the prevalence of chronic kidney disease (CKD) is 2.3  %, double that of the general population when adjusted for age, and prevalence doubles with every 10-year increase in age [2]. One major risk factor for CKD is repeated administration of nephrotoxic antibiotics, such as aminoglycosides and polymyxin E (colistin), to treat pulmonary exacerbations.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research