Structural basis of properties, mechanisms, and channelopathy of cyclic nucleotide-gated channels

This article summarizes recent advances in CNG channel structural biology, describes key structural features and elements, and illuminates a detailed conformational landscape of activation by cyclic nucleotides. The review also correlates structures with findings and properties delineated in functional studies, including nonselective monovalent cation selectivity, Ca2+ permeation and block, block by L-cis-diltiazem, location of the activation gate, lack of voltage-dependent gating, and modulation by lipids and calmodulin. A perspective on future research is also offered.PMID:37905307 | DOI:10.1080/19336950.2023.2273165
Source: Channels - Category: Molecular Biology Authors: Source Type: research