Rethinking NBM DBS: Intermittent stimulation improves sustained attention in Parkinson's disease

Degeneration of the Nucleus Basalis of Meynert (NBM) has been implicated in the cognitive decline in Parkinson's disease (PD) [1] and has therefore been a target of interest for deep brain stimulation (DBS). We have previously published on the feasibility and safety of NBM and globus pallidus interna stimulation in PD with advanced cognitive impairment [2]. The NBM was programmed to performance on sustained attention as it is a sensitive marker of cholinergic activity [3] and is crucial to several activities of daily living [4].
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Source Type: research