Front Cover: The Bioactive Dietary Polyphenol Preparation Alleviates Depression and Anxiety ‐Like Behaviors by Modulating the Regional Heterogeneity of Microglia Morphology

Mol. Nutr. Food Res. 2023,67,202300156DOI:10.1002/mnfr.202300156In article2300156, Eun-Jeong Yang, Tal Frolinger, Umar Haris Iqbal, James Murrough, and Giulio M. Pasinetti finding suggest regional heterogeneity in microglial responses following chronic stress in subregions of the corticolimbic circuit, specifically through the pathway of inflammatory activation mediated by HMGB1-RAGE. This might provide a new avenue for therapeutic intervention in stress-induced anxiety and depression-like behaviors, using a bioavailable dietary polyphenol preparation (BDPP).
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Front Cover Source Type: research