Cone-driven strong flash electroretinograms in healthy adults: Prevalence of negative waveforms

ConclusionsOver 20% of eyes showed b/a ratios less than 1, consistent with the notion that dark-adapted cone-driven responses to standard bright flashes can have  negative waveforms. The majority had ratios greater than 1. Thus, whilst selective loss of rod function can yield a negative waveform (with reduced a-wave) in some, our findings also suggest that loss of rod function can occur without necessarily yielding a negative ERG. One potential limitation is possible mild cone system adaptation by the background.

Source: Documenta Ophthalmologica - November 4, 2023 Category: Opthalmology Source Type: research